Prior to joining Altos, Adam was an Associate Professor and the Herbert Boyer Junior faculty endowed chair in the Department of Biochemistry and Biophysics at the University of California, San Francisco, a Chan Zuckerburg Investigator, and a HHMI faculty scholar. The Frost laboratory studies the behavior of molecular networks that govern homeostasis. By integrating atomic-scale structure determination by cryo-EM with genetics, biochemistry, and other imaging techniques, the Frost lab determined central mechanisms governing the shapes and connectivities of cellular organelles. The Frost lab also contributes to our understanding of how cells regulate protein synthesis levels in response to cellular stress, from translation initiation control to the detection and degradation of problematic nascent proteins. Adam's awards include the NIH Director's New Innovator Award and the Searle Scholars Award.